DR MANISH-2.pdf laser proctology piles and fistula
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Get the best piles and fistula treatment in Jaipur with advanced laser proctology techniques. Dr. Manish Rajput, a renowned specialist, provides painless, quick, and highly effective treatments for piles, fissures, and fistula. Using cutting-edge laser technology, the procedures ensure minimal discomfort, no stitches, and faster recovery, helping patients return to their daily lives with ease. Dr. Rajput is committed to offering personalized care and long-term solutions, ensuring lasting relief and improved quality of life. With his expertise and modern facilities, you can expect safe and reliable treatment for all proctological conditions.
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Presentation Overview
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• Arterial and Venous Drainage
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1. Tip (Apex): The most anterior and mobile part.
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3.2 Fungiform Papillae
• Mushroom-shaped, scattered on the anterior 2/3 of the tongue.
• Contain taste buds.
• Innervated by the Facial Nerve (CN VII) via Chorda Tympani.
3.3 Foliate Papillae
• Located on the posterolateral sides of the tongue.
• Contain taste buds.
3.4 Filiform Papillae
• Most numerous but do not contain taste buds.
• Provide mechanical function by enhancing friction between food and the tongue.
4. Muscles of the Tongue
The tongue consists of two muscle groups:
4.1 Intrinsic Muscles (Shape and Movement)
• Superior Longitudinal
• Inferior Longitudinal
• Transverse
• Vertical
4.2 Extrinsic Muscles (Positioning and Function)
• Genioglossus
• Hyoglossus
• Styloglossus
• Palatoglossus
Each muscle has a specific origin, insertion, course, and function that aids in swallowing, articulation, and movement of the tongue.
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• Contain taste buds and are innervated by the Glossopharyngeal Nerve (CN IX), despite being in the anterior 2/3 region.
3.2 Fungiform Papillae
• Mushroom-shaped, scattered on the anterior 2/3 of the tongue.
• Contain taste buds.
• Innervated by the Facial Nerve (CN VII) via Chorda Tympani.
3.3 Foliate Papillae
• Located on the posterolateral sides of the tongue.
• Contain taste buds.
3.4 Filiform Papillae
• Most numerous but do not contain taste buds.
• Provide mechanical function by enhancing friction between food and the tongue.
4. Muscles of the Tongue
The tongue consists of two muscle groups:
4.1 Intrinsic Muscles (Shape and Movement)
• Superior Longitudinal
• Inferior Longitudinal
• Transverse
• Vertical
4.2 Extrinsic Muscles (Positioning and Function)
• Genioglossus
• Hyoglossus
• Styloglossus
• Palatoglossus
Each muscle has a specific origin, insertion, course, and function that aids in swallowing, articulation, and movement of the tongue.
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individual pharmacological
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Through real-world examples, we will demonstrate how WH3 enables flexible deployment, whether on-premises, in the cloud, or hybrid, to accommodate a variety of workflows, from whole-genome sequencing (WGS) trios to high-throughput panel processing. Attendees will gain insights into:
Unifying disparate secondary analysis pipelines in WH3 for a streamlined workflow.
Customizing pipelines with user-defined inputs, modular steps, and external tool integration.
Leveraging WH3’s infrastructure flexibility to optimize performance for specific project needs.
Seamlessly connecting secondary pipelines to tertiary analysis for efficient variant interpretation.
Join us as we showcase how WH3 empowers clinical labs with the adaptability and scalability needed to meet the evolving demands of genomic analysis.
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Introduction to diagnostic laboratory
What is lab
Learning Objectives
• What is a Laboratory
• Different types of Laboratory
• Understand the role of the clinical laboratory in healthcare.
• Identify the different types of laboratory departments.
• Clinical Lab Instruments
What is a Laboratory?
•A laboratory is a controlled environment where scientific experiments, tests, and analyses are
conducted.
•It is equipped with specialized instruments, tools, and reagents to perform specific tasks.
•Laboratories play a critical role in advancing science, medicine, and technology.
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•A facility where tests are performed on clinical
specimens to diagnose, monitor, and treat diseases.
•Provides critical information for patient care.
Integrating Biomarker Testing Into Alzheimer’s Disease Workflows: Tools and S...
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Like most residents of western Europe I thought little about Malaria until I had opportunity to travel to Africa. My destination in Southern Botswana was not on the malaria map. However, parts of the North of the country to which I intended to travel were. People told me I needed to get malaria tablets that had to be taken for a week or two in advance, then daily or weekly and for some time after leaving malaria areas. There were a few different medications and combination tablets available and I investigated which would be the lesser evil. None seemed particularly effective so I decided to check the evidence of the mosquito cause of malaria and how these tablets were supposed to act. I soon became suspicious of the complicated malaria transmission story.
I have written a book 'Malaria is Spread by Mosquitos?'.
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1. Safety and Tolerability – Identifying potential side effects and the maximum tolerated dose.
2. Pharmacokinetics (PK) – Studying drug absorption, distribution, metabolism, and excretion (ADME).
3. Pharmacodynamics (PD) – Understanding the drug’s biological effects and mechanism of action.
4. Dose Escalation and Determination – Establishing the optimal dosage for further trials.
These trials are usually open-label (no placebo control) and can be conducted in different designs, such as single ascending dose (SAD), multiple ascending dose (MAD), and food effect studies. While most drugs fail in this phase due to safety concerns, successful candidates proceed to Phase 2 trials, where efficacy is further evaluated.
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USFDA GLP Regulations The U.S. Food and Drug Administration (USFDA) established Good Laboratory Practice regulations under 21 CFR Part 58. These regulations outline responsibilities for study directors, testing facilities, and personnel to maintain quality and integrity in non-clinical laboratory studies. The regulations cover various aspects, including study conduct, reporting, and archiving, ensuring consistency and accuracy in laboratory research.
Controlling the GLP Inspection Process
Regulatory authorities conduct inspections to verify GLP compliance. Laboratories must prepare for inspections by:
• Maintaining up-to-date documentation.
• Conducting internal audits.
• Ensuring personnel training and awareness.
• Implementing corrective actions for non-compliance.
Regulatory inspections typically assess laboratory infrastructure, personnel competence, study documentation, and adherence to protocols. Laboratories must demonstrate transparency and proactive quality control measures.
Documentation in GLP
Accurate and comprehensive documentation is crucial in GLP compliance. Key documentation elements include:
• Study protocols
• Standard operating procedures (SOPs)
• Raw data records
• Analytical reports
• Audit reports
• Equipment calibration records
• Archiving and retention policies
Proper documentation ensures traceability, accountability, and reliability in laboratory research.
Audit in GLP Compliance
Auditing is a critical component of GLP, ensuring adherence to established regulations and identifying areas for improvement. Audits can be internal (self-audit) or external (regulatory or third-party audits).
Goals of Laboratory Quality Audit
• Ensure compliance with GLP regulations.
• Identify gaps and areas for improvement.
• Validate data integrity and accuracy.
• Enhance operational efficiency.
• Prevent regulatory penalties and study disqualification.
Audit Tools in GLP
Laboratories use various audit tools to assess compliance, including:
• Checklists and self-assessments
• Internal quality audits
• Electronic data tracking systems
• Third-party inspections
• Root cause analysis
• Corrective and preventive action (CAPA) plans
Future of GLP Regulations
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Introduction
Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked seizures. It affects millions of people worldwide, cutting across all age groups and ethnicities. Seizures result from excessive and abnormal cortical nerve cell activity in the brain, leading to temporary changes in movement, sensation, behavior, or consciousness. This document provides a comprehensive overview of epilepsy, including its causes, classification, symptoms, diagnosis, and management strategies.
Causes of Epilepsy
Epilepsy can arise due to multiple factors, including genetic predisposition, brain injuries, infections, or developmental disorders. Some common causes include:
Genetic Factors: Certain types of epilepsy have a hereditary component, suggesting that genetic mutations may contribute to its development.
Brain Trauma: Head injuries from accidents or sports activities can lead to epilepsy.
Stroke and Vascular Diseases: Stroke, which reduces oxygen supply to the brain, is a leading cause of epilepsy in older adults.
Infections: Conditions such as meningitis, encephalitis, and neurocysticercosis can trigger epilepsy.
Developmental Disorders: Disorders such as autism and neurofibromatosis have been linked to epilepsy.
Tumors and Structural Abnormalities: Brain tumors and congenital malformations can also lead to epileptic seizures.
Classification of Epilepsy
The International League Against Epilepsy (ILAE) classifies epilepsy based on the nature of seizures and their origin in the brain:
Focal (Partial) Seizures: Originate in one part of the brain and can be simple (without loss of consciousness) or complex (with impaired consciousness).
Generalized Seizures: Involve both hemispheres of the brain and include types such as absence, tonic-clonic, myoclonic, and atonic seizures.
Unknown Onset Seizures: When the starting point of the seizure is unclear.
Epilepsy Syndromes: Specific syndromes such as Lennox-Gastaut syndrome, Dravet syndrome, and Juvenile Myoclonic Epilepsy have distinct features and management strategies.
Symptoms of Epilepsy
The clinical manifestations of epilepsy depend on the type of seizure and the brain region involved. Symptoms may include:
Temporary confusion or staring spells
Uncontrollable jerking movements (convulsions)
Loss of consciousness or awareness
Sensory disturbances such as tingling or hallucinations
Emotional changes, anxiety, or déjà vu
Diagnosis of Epilepsy
A thorough medical evaluation is necessary to diagnose epilepsy accurately. The diagnostic process includes:
Medical History and Physical Examination: A detailed history of seizure episodes, triggers, and associated conditions is crucial.
Electroencephalogram (EEG): Measures electrical activity in the brain and identifies abnormal patterns suggestive of epilepsy.
Neuroimaging (MRI, CT Scan): Detects structural abnormalities, tumors, or brain injuries.
Blood Tests: Helps rule out metabolic or i
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DR MANISH-2.pdf laser proctology piles and fistula
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